Enes K. Ergin, PhD
Bioinformatician & Systems Engineer
Founder at Zenteomics - GitHub
Bioinformatician at the Lange Lab, BC Children's Hospital Research Institute
PhD, Bioinformatics. University of British Columbia
I work on quantitative proteomics, proteoform analysis, multi-omics integration, and machine learning for pediatric cancer research. I build software and reproducible analysis workflows when existing tools do not match the biological question. I am the founder of Zenteomics, focused on proteomics data infrastructure and open-source tooling for mass spectrometry.
Research interests
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Quantitative proteomics & proteoform biology
Developing methods for differential proteoform discovery, protein equivalence testing, and PTM-aware quantitative analysis. My work here includes ProteoForge, QuEStVar, and SQuAPP.
ProteoForge J. Proteome Res., 2026 · QuEStVar J. Proteome Res., 2024 · SQuAPP Bioinformatics, 2022 · N-termini proteoforms (Weng et al.) Mol. Cell. Proteomics, 2019 -
Statistical methods & equivalence testing
Designing statistical frameworks for proteomics that go beyond differential expression. QuEStVar introduced equivalence-based testing for identifying conserved functional modules across biological systems.
QuEStVar J. Proteome Res., 2024 · QuEStVar Analysis GitHub -
Pediatric cancer multi-omics
Applying proteomics, phosphoproteomics, and integrative analysis to pediatric acute lymphoblastic leukemia and other childhood cancers. Translational work through the PROFYLE initiative and PDX model characterization.
PROFYLE (Barnabas et al.) EMBO Mol. Med., 2025 · ALL proteomics (Lorentzian et al.) Nature Comms., 2023 · PDX models (Uzozie et al.) J. Exp. Clin. Cancer Res., 2021 -
Mass spectrometry data infrastructure
Building fast, dependency-free tools in Zig and Python for spectral compression, format validation, dataset discovery, calibration curves, and FAIR metadata auditing.
pxseek ProteomeXchange querying, 2026 · z-fasta SIMD indexer, 2026 · mzarc Spectral compression, 2026 · loqculate LOD/LOQ estimation, 2026 · PXAudit FAIR metadata audit, 2026 · mzValidate mzML validator, 2026